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KEY PAPERS
Peptide Transport
1. Brandsch, M., Miyamoto, Y., Ganapathy, V., Leibach, F.H. (1994)
Expression and protein kinase C-dependent regulation of peptide/H+ co-transport system in the Caco-2 human colon carcinoma cell line
Biochem. J. 299, 253-260
2. Brandsch, M., Brandsch, C., Prasad, P.D., Ganapathy, V., Hopfer, U., Leibach, F.H. (1995)
Identification of a renal cell line that constitutively expresses the kidney-specific high-affinity H+/peptide cotransporter
FASEB J. 9, 1489-1496
3. Brandsch, M., Thunecke, F., Küllertz, G., Schutkowski, M., Fischer, G., Neubert, K. (1998)
Evidence for the absolute conformational specificity of the intestinal H+/peptide symporter, PEPT1
J. Biol. Chem. 273, 3861-3864
4. Knütter, I., Theis, S., Hartrodt, B., Born, I., Brandsch, M., Daniel, H., Neubert, K. (2001)
A novel inhibitor of the mammalian peptide transporter PEPT1
Biochemistry 40, 4454-4458
5. Knütter, I., Rubio-Aliaga, I., Boll, M., Hause, G., Daniel, H., Neubert, K., Brandsch, M. (2002)
H+-peptide cotransport in the human bile duct epithelium cell line SK-ChA-1
Am. J. Physiol. 283, G222-G229
Amino Acid Transport
1. Brandsch, M., Ramamoorthy, S., Marczin, N., Catravas, J.D., Leibach, J.W., Ganapathy, V., Leibach, F.H. (1995)
Regulation of taurine transport by Escherichia coli heat-stable enterotoxin and guanylin in human intestinal cell lines
J. Clin. Invest. 96, 361-369
2. Grafe, F., Wohlrab, W., Neubert, R., Brandsch, M. (2004)
Functional characterization of sodium- and chloride-dependent taurine transport in human keratinocytes
Eur. J. Pharm. Biopharm. 57, 337-341
3. Metzner, L., Kottra, G., Neubert, K., Daniel, H., Brandsch, M. (2005)
Serotonin, L-tryptophan, and tryptamine are effective inhibitors of the amino acid transport system PAT1
FASEB J. 19, 1468-1473
4. Metzner, L., Natho, K., Zebisch, K., Dorn, M., Bosse-Doenecke, E., Ganapathy, V., Brandsch, M. (2008)
Mutational analysis of histidine residues in the human proton-coupled amino acid transporter PAT1
Biochim. Biophys. Acta 1778, 1042-1050
5. Dorn, M., Weiwad, M., Markwardt, F., Laug, L., Rudolph, R., Brandsch, M., Bosse-Doenecke, E. (2009)
Identification of a disulfide bridge essential for transport function of the human proton-coupled amino acid transporter hPAT1
J. Biol. Chem. 284, 22123-22132
Organic Cation Transport
1. Hoffmann, K., Grafe, F., Wohlrab, W., Neubert, R.H., Brandsch, M. (2002)
Functional characterization of a high-affinity choline transport system in human keratinocytes
J. Invest. Dermatol. 119, 118-121
2. Müller, J., Lips, K.S., Metzner, L., Neubert, R.H.H., Koepsell, H., Brandsch, M. (2005)
Drug specificity and intestinal membrane localization of human organic cation transporters (OCT)
Biochem. Pharmacol. 70, 1851-1860
3. Fischer, W., Neubert, R.H.H., Brandsch, M. (2010)
Transport of phenylethylamine at intestinal epithelial (Caco-2) cells: Mechanism and substrate specificity
Eur. J. Pharm. Biopharm. 74, 281-289
Drug Transport
1. Ganapathy, M.E., Brandsch, M., Prasad, P.D., Ganapathy, V., Leibach, F.H. (1995)
Differential recognition of ß-lactam antibiotics by intestinal and renal peptide transporters, PEPT 1 and PEPT 2
J. Biol. Chem. 270, 25672-25677
2. Bretschneider, B., Brandsch, M., Neubert, R. (1999)
Intestinal transport of ß-lactam antibiotics: analysis of the affinity at the H+/peptide symporter (PEPT1), the uptake into Caco-2 cell monolayers and the transepithelial flux
Pharm. Res. 16, 55-61
3. Metzner, L., Kalbitz, J., Brandsch, M. (2004)
Transport of pharmacologically active proline derivatives by the human proton-coupled amino acid transporter hPAT1
J. Pharmacol. Exp. Ther. 309, 28-35
4. Knütter, I., Wollesky, C., Kottra, G., Hahn, M.G., Fischer, W., Zebisch, K., Neubert, R.H.H., Daniel, H., Brandsch, M. (2008)
Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited
J. Pharmacol. Exp. Ther. 327, 432-441
5. Metzner, L., Dorn, M., Markwardt, F., Brandsch, M. (2009)
The orally active antihyperglycemic drug ß-guanidinopropionic acid is transported by the human proton-coupled amino acid transporter hPAT1
Mol. Pharmaceutics 6, 1006-1011
Other
1. Grafe, F., Wohlrab, W., Neubert, R.H., Brandsch, M. (2003)
Transport of biotin in human keratinocytes
J. Invest. Dermatol. 120, 428-433
2. Poeaknapo, C., Schmidt, J., Brandsch, M., Dräger, B. Zenk, M.H. (2004)
Endogenous formation of morphine in human cells
Proc. Natl. Acad. Sci. USA 101, 14091-14096
3. Grunwald, S., Krause, R., Bruch, M., Henle, T., Brandsch, M. (2006)
Transepithelial flux of early and advanced glycation compounds across Caco-2 cell monolayers and their interaction with intestinal amino acid and peptide transport systems
Br. J. Nutr. 95, 1221-1228
4. Zhang, L., Laug, L., Münchgesang, W., Pippel, E., Gösele, U., Brandsch, M., Knez, M. (2010)
Reducing stress on cells with apoferritin-encapsulated platinum nanoparticles
Nano Lett. 10, 219-223
Major Reviews
1. Ganapathy, V., Brandsch, M., Leibach, F.H. (1994)
Intestinal Transport of Amino Acids and Peptides
In: Physiology of the Gastrointestinal Tract , Raven Press - New York
2. Brandsch, M., Ganapathy, V., Leibach, F.H. (1995)
Role of dipeptidyl peptidase IV (DP IV) in intestinal and renal absorption of peptides
In: Dipeptidyl Peptidase IV (CD26) in Metabolism and the Immune Response Springer - Heidelberg & R.G. Landes Company - Austin
3. Brandsch, M., Knütter, I., Leibach, F.H. (2004)
The intestinal H+/peptide symporter PEPT1: structure-affinity relationships
Eur. J. Pharm. Sci. 21, 53-60
4. Brandsch, M., Knütter, I., Bosse-Doenecke, E. (2008)
Pharmaceutical and pharmacological importance of peptide transporters
J. Pharm. Pharmacol. 60, 543-585
5. Brandsch, M. (2009)
Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls
Expert Opin. Drug Metab. Toxicol. 5, 887-905
For other Publications, Impact Factors, Citation Reports and h-Index of Authors see ISI Web of Knowledge