Martin-Luther-Universität Halle-Wittenberg


Peptide Transport

1. Brandsch, M., Miyamoto, Y., Ganapathy, V.,  Leibach, F.H. (1994)
Expression  and protein kinase C-dependent regulation of peptide/H+ co-transport system in the Caco-2 human colon carcinoma cell line    
Biochem. J. 299, 253-260

2. Brandsch, M., Brandsch, C., Prasad,  P.D., Ganapathy, V., Hopfer, U., Leibach, F.H. (1995)
Identification of  a renal cell line that constitutively expresses the kidney-specific  high-affinity H+/peptide cotransporter    
FASEB J.  9, 1489-1496

3. Brandsch, M., Thunecke, F., Küllertz, G.,  Schutkowski, M., Fischer, G., Neubert, K. (1998)
Evidence  for the absolute conformational specificity of the intestinal H+/peptide  symporter, PEPT1    
J. Biol. Chem. 273, 3861-3864

4.  Knütter, I., Theis, S., Hartrodt, B., Born, I., Brandsch, M., Daniel,  H., Neubert, K. (2001)
A  novel inhibitor of the mammalian peptide transporter PEPT1    
Biochemistry 40, 4454-4458

5. Knütter, I., Rubio-Aliaga, I.,  Boll, M., Hause, G., Daniel, H., Neubert, K., Brandsch, M. (2002)
H+-peptide  cotransport in the human bile duct epithelium cell line SK-ChA-1    
Am. J. Physiol. 283, G222-G229

Amino Acid Transport

1.  Brandsch, M., Ramamoorthy, S., Marczin, N., Catravas, J.D.,  Leibach, J.W., Ganapathy, V., Leibach, F.H. (1995)
Regulation of  taurine transport by Escherichia coli heat-stable  enterotoxin and guanylin in human intestinal cell lines    
J. Clin.  Invest. 96, 361-369

2. Grafe, F., Wohlrab, W., Neubert, R.,  Brandsch, M. (2004)
Functional  characterization of sodium- and chloride-dependent taurine  transport in human keratinocytes    
Eur. J. Pharm. Biopharm. 57,  337-341

3. Metzner, L., Kottra, G., Neubert, K., Daniel, H.,  Brandsch, M. (2005)
Serotonin, L-tryptophan, and tryptamine are  effective inhibitors of the amino acid transport system PAT1    
FASEB J. 19, 1468-1473

4. Metzner, L., Natho, K., Zebisch, K.,  Dorn, M., Bosse-Doenecke, E., Ganapathy, V., Brandsch, M. (2008)
Mutational analysis of histidine  residues in the human proton-coupled amino acid transporter PAT1    
Biochim. Biophys. Acta 1778, 1042-1050

5. Dorn, M., Weiwad, M.,  Markwardt, F., Laug, L., Rudolph, R., Brandsch, M., Bosse-Doenecke,  E. (2009)
Identification of a disulfide bridge  essential for transport function of the human proton-coupled amino  acid transporter hPAT1    
J. Biol. Chem. 284, 22123-22132

Organic Cation Transport

1. Hoffmann, K., Grafe, F., Wohlrab, W.,  Neubert, R.H., Brandsch, M. (2002)
Functional  characterization of a high-affinity choline transport system in  human keratinocytes    
J. Invest. Dermatol. 119, 118-121

2.  Müller, J., Lips, K.S., Metzner, L., Neubert, R.H.H.,  Koepsell, H., Brandsch, M. (2005)
Drug  specificity and intestinal membrane localization of human organic  cation transporters (OCT)    
Biochem. Pharmacol. 70,  1851-1860

3. Fischer, W., Neubert, R.H.H., Brandsch, M.  (2010)
Transport  of phenylethylamine at intestinal epithelial (Caco-2) cells: Mechanism  and substrate specificity    
Eur. J. Pharm. Biopharm. 74, 281-289

Drug Transport

1. Ganapathy, M.E., Brandsch, M., Prasad,  P.D., Ganapathy, V., Leibach, F.H. (1995)
Differential  recognition of ß-lactam antibiotics by intestinal and renal peptide  transporters, PEPT 1 and PEPT 2    
J. Biol. Chem. 270, 25672-25677

2.  Bretschneider, B., Brandsch, M., Neubert, R. (1999)
Intestinal  transport of ß-lactam antibiotics: analysis of the affinity at the H+/peptide  symporter (PEPT1), the uptake into Caco-2 cell monolayers and the  transepithelial flux    
Pharm. Res. 16, 55-61

3. Metzner, L.,  Kalbitz, J., Brandsch, M. (2004)
Transport  of pharmacologically active proline derivatives by the human proton-coupled  amino acid transporter hPAT1    
J. Pharmacol. Exp. Ther. 309,  28-35

4. Knütter, I., Wollesky, C., Kottra, G., Hahn, M.G.,  Fischer, W., Zebisch, K., Neubert, R.H.H., Daniel, H., Brandsch, M.  (2008)
Transport of angiotensin-converting  enzyme inhibitors by H+/peptide transporters revisited    
J. Pharmacol. Exp. Ther. 327, 432-441

5. Metzner, L., Dorn, M.,  Markwardt, F., Brandsch, M. (2009)
The orally active  antihyperglycemic drug ß-guanidinopropionic acid is  transported by the human proton-coupled amino acid transporter  hPAT1    
Mol. Pharmaceutics 6, 1006-1011


1.  Grafe, F., Wohlrab, W., Neubert, R.H., Brandsch, M. (2003)
Transport  of biotin in human keratinocytes    
J. Invest. Dermatol. 120,  428-433

2. Poeaknapo, C., Schmidt, J., Brandsch, M., Dräger, B.  Zenk, M.H. (2004)
Endogenous  formation of morphine in human cells    
Proc. Natl. Acad. Sci. USA  101, 14091-14096

3. Grunwald, S., Krause, R., Bruch, M., Henle,  T., Brandsch, M. (2006)
Transepithelial  flux of early and advanced glycation compounds across Caco-2 cell  monolayers and their interaction with intestinal amino acid and peptide  transport systems    
Br. J. Nutr. 95, 1221-1228

4. Zhang, L.,  Laug, L., Münchgesang, W., Pippel, E., Gösele, U., Brandsch, M., Knez,  M. (2010)
Reducing stress  on cells with apoferritin-encapsulated platinum nanoparticles    
Nano Lett. 10, 219-223

Major Reviews

1. Ganapathy,  V., Brandsch, M., Leibach, F.H. (1994)
Intestinal Transport of  Amino Acids and Peptides
In: Physiology  of the Gastrointestinal Tract     , Raven Press - New York

2.  Brandsch, M., Ganapathy, V., Leibach, F.H. (1995)
Role of  dipeptidyl peptidase IV (DP IV) in intestinal and renal absorption of  peptides
In: Dipeptidyl  Peptidase IV (CD26) in Metabolism and the Immune Response     Springer -  Heidelberg & R.G. Landes Company - Austin

3. Brandsch,  M., Knütter, I., Leibach, F.H. (2004)
The  intestinal H+/peptide symporter PEPT1: structure-affinity  relationships    
Eur. J. Pharm. Sci. 21, 53-60

4. Brandsch,  M., Knütter, I., Bosse-Doenecke, E. (2008)
Pharmaceutical and pharmacological  importance of peptide transporters    
J. Pharm. Pharmacol. 60,  543-585

5. Brandsch, M. (2009)
Transport of drugs by proton-coupled  peptide transporters: pearls and pitfalls    
Expert Opin. Drug  Metab. Toxicol. 5, 887-905

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